Incubus Dreams continues the adventures of Anita Blake. In this novel, Anita's romantic life undergoes a dramatic upheaval while she simultaneously attempts to assist the police in solving a series of vampire serial murders. As with the other later novels in the series, Incubus Dreams blends elements of supernatural, detective, and erotic fiction.

Similar to most of the books in the Anita Blake series, Incubus Dreams is titled after a fictional location within the book. In this case, "Incubus Dreams" is the name of a strip club where some of the later events in the book occur.